TGFB2 and open-angle glaucoma: Nevertheless, increased levels of transforming growth factor-β2 (TGF-β2) in the AH of POAG patients (Tripathi et al., 1994) and its role in decreasing the activity of matrix metalloproteinases (MMPs) suggest that the abnormal ECM deposits may be due to decreased ECM turnover (Fuchshofer et al., 2003; Tamm and Fuchshofer, 2007).