EPHX2 and obesity due to melanocortin 4 receptor deficiency: Augmenting the effects of EETs hasthe potential to exert powerful influences on metabolic cardiovasculardisease associated with obesity., It is worthnoting that, among the EETs, 14,15-EET is highly unstable and rapidlydegrades into 14,15-DHET, which exhibits low activity in the presenceof sEH.