NME1 and neoplasm: However, although a direct link between the expressions of this protein and EGFR mutation has not been conclusively established, it has already been identified as a promising prognostic marker for NSCLC: Lower nucleoside diphosphate kinase A expression was strongly associated with increased risk of NSCLC, advanced TNM staging, poorer tumor differentiation, positive lymph node metastasis, lung adenocarcinoma, and a lower 5‐year overall survival rate in NSCLC patients [56].