Several proteins were found in significantly higher levels in SSc‐ILD after 6 months, notably cytoskeleton proteins (TLN1, CFL1, ACTN1, PFN1, VCL, ACTB), THBS1 (platelet aggregation, cell‐to‐matrix interactions) and CXCL17 (released by platelets, synthesis of ECM) (Fig. 7A,B). Here, ACTN1 is linked to systemic sclerosis.