Results also showed decreased levels of the proteins IGHM (immunoglobulin μ chain C region, which defines the IgM isotype) and JCHAIN (which favors the multimerization and secretion of IgM and IgA) in the 20 SSc patients with ILD progression (Cohort 2) (Fig. 6E). The gene discussed is CD79A; the disease is interstitial lung disease.