SSc‐no ILD patients, compared to HVs, presented with a lower frequency of CD8+ T naïve cells (CD8+ CD45RA+ CD27+) and an increased frequency of CD8+ effector T cells (CD45RA+ CD27‐) (Fig. 5B) and of CD56‐ CD16+ NK cells (Fig. 5C). Here, CD27 is linked to systemic sclerosis.