Our results confirm the involvement of pro‐inflammatory mechanisms in SSc‐related ILD, with elevated type 1 interferon (IFN1), fractalkine (CX3CL1), and C‐C motif chemokine 2 (CCL2), as well as the profibrotic markers C‐X‐C motif chemokine 17 (CXCL17), thrombospondin (THBS), and latent transforming growth factor beta‐binding protein 1 (LTBP1). Here, CX3CL1 is linked to interstitial lung disease.