Several proteins were found in significantly higher levels in SSc‐ILD after 6 months, notably cytoskeleton proteins (TLN1, CFL1, ACTN1, PFN1, VCL, ACTB), THBS1 (platelet aggregation, cell‐to‐matrix interactions) and CXCL17 (released by platelets, synthesis of ECM) (Fig. 7A,B). The gene discussed is PFN1; the disease is systemic sclerosis.