Several proteins were found in significantly higher levels in SSc‐ILD after 6 months, notably cytoskeleton proteins (TLN1, CFL1, ACTN1, PFN1, VCL, ACTB), THBS1 (platelet aggregation, cell‐to‐matrix interactions) and CXCL17 (released by platelets, synthesis of ECM) (Fig. 7A,B). This evidence concerns the gene ACTB and systemic sclerosis.