They are responsible, amongst other things, for structural support by assembling into a sheet‐like polymeric network, like type IV collagen, via the N‐ter of αβγ chains mediated by Ca2+ ions.[48, 49, 50, 51] In GBM, the main isoform in the GBM is laminin‐α5β2γ1, however, at embryonic stages, laminin is present in the isoform α1β1γ1, which transitions into α5β1γ1 then α5β2γ1, each form being crucial as a mutation in either one of them results in genetic diseases.[52]. This evidence concerns the gene LAMB2 and glioblastoma.