Notably, studies in HT-1080 fibrosarcoma cells suggest that HIF-1αinhibits ferroptosis by upregulating fatty acid-binding proteins 3 and 7 (FABP3/7).15 EPAS1-encoded HIF-2αis a critical driver of clear-cell renal cell carcinoma. The gene discussed is FABP3; the disease is clear cell renal carcinoma.