GSDMD and Cognitive impairment: 2018). Upon activation, NLRP3 promotes the cleavage of pro‐Casp‐1 into its active form, which in turn cleaves gasdermin D (GSDMD), facilitating the maturation and release of interleukins IL‐1β and IL‐18. This process leads to pyroptosis, a proinflammatory form of programmed cell death (McKenzie et al. 2018, Fann et al. 2018, Ren et al. 2018). The resulting inflammatory cascade contributes to neuronal damage and cognitive impairment, which are believed to exacerbate depressive symptoms (You et al. 2011, Czeh and Nagy 2018).