Whereas interactions necessary of T‐cell activation, like MIF (interacting with CXCR4, CD74 and CD44), PPIA (interacting with BSG) and CXCL16 (interacting with CXCR6 on CD8+ T‐cells) were down‐regulated in high EGFR expressing tumour cells. This evidence concerns the gene CD44 and neoplasm.