CD8A and cancer: The occurrence and progression of malignant tumors are closely related to immune function, particularly cellular immune function, which involves immune responses primarily mediated by CD3+, CD4+, and CD8+ cells.11 The present study revealed that after treatment, the levels of CD3+, CD4+, and CD4+/CD8+ were higher in the study group compared to the control group (all p = 0.00).