Adiponectin is involved in metabolic processes including adipose tissue catabolism and glucose level.6 Some research findings proposed that higher prevalence of SNP rs1501299 (276 G>T) variant of ADIPOQ is associated with the risk of pathogenesis of PCOS.7,8 Genetic association studies on PCOS in the Pakistani population are scarce.9,10 Particularly there are no data published on the genetic predisposition of PCOS in Southern Punjab. Here, ADIPOQ is linked to polycystic ovary syndrome.