Rats in MCAO group and lv-NC group had decreased rota-rod duration compared with sham rats (p < 0.01), while rats in lv-ATF3 group exhibited a significant increase in duration on the rota-rod compared with MCAO and lv-NC rats (p < 0.01) (Figure 3G), which indicated that silencing ATF3 could improve the motor coordination of stroke rats. This evidence concerns the gene ATF3 and stroke disorder.