ATF3 and ischemic stroke: Next, silencing ATF3 considerably suppressed the expression of p-ERK/ERK, and anisomycin, the MAPK pathway agonist, reversed the effects of silencing ATF3 on ischemic stroke and mitochondrial homeostasis, indicating that silencing ATF3 attenuated ischemic stroke and regulated mitochondrial homeostasis via the MAPK signaling pathway.