ABCD3 and myeloid sarcoma: Given that fibroblasts from patients with PMP70 deficiencies exhibit normal rates of β-oxidation of the VLCFA C26:0 (Ferdinandusse et al., 2015), it is probable that the reduction in PMP70-positive neurons in MS reflects an overall decrease in peroxisome number/function, which limits the rate of peroxisomal β-oxidation and exacerbates the inflammation and demyelination phenotypes via VLCFA accumulation.