Confirming the importance of peroxisome dynamics for neuronal health, multiple PEX11β-deficient patients have been identified, presenting with neurological symptoms reminiscent of a mild peroxisomal biogenesis disorder, despite mainly normal biochemical parameters (Ebberink et al., 2012; Tian et al., 2020). This evidence concerns the gene PEX11B and Peroxisome biogenesis disorder-Zellweger syndrome spectrum.