Interestingly, mutations in the lipid-transfer protein VPS13D (vacuolar protein sorting 13D), which mediates peroxisome biogenesis and localizes to multiple MCSs including peroxisome-ER, lead to neurological disorders with ataxia phenotypes (Baldwin et al., 2021; Guillén-Samander et al., 2021). The gene discussed is VPS13D; the disease is cerebellar ataxia.