While the downregulated (Supplementary Table 13) DEGs in the Control vs. Poly I: C treated group of Gaddi dogs showed pathways highlighting, such as in cancer with NOTCH2, MDM2, and E2F3, the pathway related to RNA metabolism was also enriched for genes such as HNRNPA3 and XPO1. This evidence concerns the gene HNRNPA3 and cancer.