For example, in breast cancer, abnormal activation of Notch1 suppresses the expression of differentiation-related genes (such as GATA3) and drives the upregulation of stem cell-related genes (such as SOX2 and OCT4), This sustains the undifferentiated state of tumor cells, enhances their proliferative capacity, and increasing drug resistance (28, 29). This evidence concerns the gene NOTCH1 and breast cancer.