Administration of M. oleifera bio actives, such as M. oleifera isothiocyanate-1 (MIC-1) or MOLP, have demonstrated a significant decrease in tissue concentration and serum of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β, in experimental models of acute inflammation or sepsis such as LPS-induced sepsis in mice (127). Here, TNF is linked to Sepsis.