SAFE score: Atrial Fibrillation in Sepsis score; SIC score: sepsis-induced coagulopathy score; APACHE II score: Acute Physiology and Chronic Health Evaluation II score; SOFA score: Sequential Organ Failure Assessment score; INR: international normalized ratio; CRP: C-reactive protein; FiO2: fraction of inspired oxygen; CHF: congestive heart failure; TNF: tumor necrosis factor; WBC: white blood cell count; SVM: support vector machine; RF: random forest; MPO: myeloperoxidase; HOCl: hypochlorous acid; APTT: activated partial thromboplastin time; PT: prothrombin time. The gene discussed is F2; the disease is atrial fibrillation.