• Italian LUTS/BPH patients previously treated with tamsulosin (0.4 mg/day) for ≥12 months • IPSS ≥8 • IPSS-QoL ≥3 • prostate volume ≤40 mL • Qmax <15 mL/s • PVR ≤150 mL • PSA <4 ng/mL. This evidence concerns the gene KLK3 and benign prostatic hyperplasia.