Ginsenosides Rg1 significantly improved cognitive impairment in D-Gal-induced alteration in the hippocampus, and downregulate age-related markers such as p53, p21 Cip1/Waf1 and p19 Arf [7] (Fig. 2 and Table 1). The gene discussed is CDKN2A; the disease is Cognitive impairment.