Alzheimer’s disease(AD), the predominant cause of dementiaglobally, is characterized by progressive cognitive decline and distinctneuropathological features, including amyloid-beta (Aβ) senileplaques, tau neurofibrillary tangles, heightened oxidative stress,and neuronal loss. Despite extensive research,the underlying mechanisms of AD pathogenesis remain insufficientlyunderstood. The gene discussed is MAPT; the disease is Alzheimer disease.