SERPINE1 and stroke disorder: Althoughthe clinical significance of this homozygous PAI-1 mutationalone is unclear, studies suggest an increased frequency of thromboticevents when it occurs alongside other prothrombotic conditions. Consequently, the prothrombotic state causedby the PAI-1 mutation predisposes individuals to venous and arterialthrombosis, increasing the risk of conditions like acute coronarysyndrome (ACS), cerebrovascular accident (CVA), and repeated abortion(RA).−, , , ,