Significantly, activated T cells play a key role in GO pathogenesis by releasing cytokines like, such as tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and interleukin-17 (IL-17) (18). Here, IL1B is linked to geroderma osteodysplastica.