The proteins were systematically annotated using the KEGG pathway database (Figure 3), tallying the DEPs associated with each pathway, and revealing diabetic cardiomyopathy (DCM), the PPAR signaling pathway, and the HIF-1 signaling pathway as the most prominent pathways (Figure 3; Data S6). The gene discussed is HIF1A; the disease is familial dilated cardiomyopathy.