DNMT3A and obesity due to melanocortin 4 receptor deficiency: A study on heterozygous DNMT3A deletion in mice demonstrated that DNMT3A-deficient mice exhibited a hypomethylated landscape, characterized by an inflammatory phenotype in adipocytes, an overall metabolic manifestation of obesity and age-related insulin resistance, and a broader spectrum of aberrantly differentiated adipocyte progenitors (54).