A study investigating the epigenetic regulator tonicity-responsive enhancer-binding protein (TonEBP) in thermogenesis and obesity found that treatment with the DNMT inhibitor RG108 (12 mg/kg, intraperitoneal injection every two days) conferred resistance to HFD-induced body weight gain and adiposity in mice, confirming that DNMT1 primarily mediates this protective effect (52). The gene discussed is DNMT1; the disease is obesity due to melanocortin 4 receptor deficiency.