Increased expression of ZEB1 has been associated with the repression of CDH1 (Zhang et al., 2019), which is associated with BE progression to EAC (Darlavoix et al., 2009; Falkenback et al., 2008; Feith et al., 2004; Kalatskaya, 2016; Yao et al., 2021). Here, ZEB1 is linked to Barrett esophagus.