For diagnostic application, ten genes—IGHV3-43, SLC38A4, PLLP, CELA3A, IGHV4-31, TMPRSS5, TP53, NR4A1, ATF3, IFI27—were identified as the top candidates for dysplasia detection, particularly for distinguishing between NDBE and LGD BE. The gene discussed is NR4A1; the disease is Barrett esophagus.