GATA1 and thalassemia: The prediction of the transcription factor binding site supported that the δ−77(T>C) disrupts the GATA-1 binding to the δ-globin gene promoter (A/T GATA A/G) [(modification from TTATCT (AGAT AA) to TCATCT (AGATCA)] (Table S2), although a low CADD score of δ−77(T>C) might be inconsistent with the δ0-thalassemia phenotype (Matsuda, Sakamoto & Fukumaki, 1992).