highlight the role of miR-141, which functions as either a tumor suppressor in different cancers, regulating tumor cell proliferation, apoptosis, invasion, and metastasis through various signaling pathways, including the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) pathway and the constitutive activation of nuclear factor-κB (NF-κB). The gene discussed is AKT1; the disease is cancer.