In addition to TGF-β1, which has been identified as the primary molecule in the development of peritoneal dysfunction and damage to peritoneal mesothelial cells (Huang et al., 2023; Si et al., 2019; Mo et al., 2023), high glucose also plays a crucial role in causing damage to mesothelial cells and peritoneal fibrosis (Krediet and Parikova, 2022; Hu et al., 2023). Here, TGFB1 is linked to Peritoneal Fibrosis.