In MCF-7 cells, quercetin induces G0/G1 arrest by downregulating survivin mRNA to promote apoptosis (Mu et al., 2007); in HepG2 hepatocellular carcinoma, it elevates p53 and p21 to block G1 progression (Kim H. et al., 2013). This evidence concerns the gene TP53 and hepatocellular carcinoma.