Guo et al. reported that quercetin elevates the SIRT1 expression level and the AMPK phosphorylation level in a dose-dependent manner, thereby activating the SIRT1/AMPK axis to trigger mitochondria-dependent apoptotic pathway in human A549 cells and H1299 cells, to treat the non-small cell lung cancer (NSCLC) (Lee et al., 2020). Here, SIRT1 is linked to non-small cell lung carcinoma.