CD28 and coronary artery disorder: For CAD, CD24+ CD27+ %B cells (OR = 0.952, 95% CI: 0.918–0.988, P = 0.01) and SSC-A on HLA DR+ NK cells (OR = 0.975, 95% CI: 0.959–0.990, P = 0.007) were protective, while lymphocyte subgroups like B cell AC and CD28- CD8br AC indicated increased risk.