Conversely, increased levels of B cells (CD27 on IgD– CD38br and CD27 on IgD+ CD38– unswitched memory), CD4 on CD39+ CD4+ (Treg), and DN (CD4–CD8–) AC (TBNK) were linked to higher ischemic stroke risk, indicating hazardous effects. This evidence concerns the gene CD8A and ischemic stroke.