The combination of B7 homolog 3 (B7H3)‐targeted CAR‐T cells and CXCL11‐armed oncolytic adenovirus achieved a sustained anti‐tumor response and reprogrammed the TME, increasing the infiltration of CD8+ T cells, NK cells, and M1‐polarized macrophages while reducing immunosuppressive cell populations. The gene discussed is CD276; the disease is neoplasm.