PLOD1 and obesity due to melanocortin 4 receptor deficiency: Several studies have published similar findings, reporting that pubertal girls with higher BMI or %BF have with lower levels of estradiol or LH [35, 41, 42], and other studies have reported a reduced nocturnal rise in LH in early pubertal girls with obesity compared with girls with average weight when adjusted for Tanner B stage [43, 44].