In contrast, distance travelled in the open field, the number of slips in the balance beam and the latency to fall in the accelerating rotarod tests were altered in wild-type mice injected with AAV-4E-BP1F113A (Fig. 2A–C) resembling motor alterations observed in HD mouse models.7,17 After performing the behavioural tests, we analyzed whether protein levels of 4E-BP2, the most abundant 4E-BP isoform in the brain,20 were altered by the expression of 4E-BP1F113A. The gene discussed is EIF4EBP2; the disease is Huntington disease.