Increased translation has been related with neuronal dysfunction occurring in several neurological and neurodegenerative diseases.6,33-35 In fact, we have previously shown in the R6/1 mouse model of HD that augmented protein synthesis in striatal DARPP-32-positive neurons was involved in their degeneration leading to motor symptoms.7 Notably, these animals exhibited altered corticostriatal long-term depression (LTD), a process involved in motor learning. This evidence concerns the gene PPP1R1B and Huntington disease.