No associations with synaptic vesicle glycoprotein 2A PET were found for synaptosomal-associated protein of 25 kDa, phosphorylated tau181, neurofilament light or amyloid-β1-42/amyloid-β1-40, likely due to the minimal presence of Alzheimer’s disease pathology in the study population. Here, SV2A is linked to early-onset autosomal dominant Alzheimer disease.