Some data suggest that for those considered hyperresponders (AFC, >15), a 150-IU daily dose of FSH significantly increase the number of oocytes collected and reduce the risk of OHSS, whereas those who are poor or normal responders are recommended to have a starting FSH dose of 150–225 or 225–300 IU (12). The gene discussed is BRD2; the disease is ovarian hyperstimulation syndrome.