SIRT5 and colorectal carcinoma: TwoSampleMR analysis revealed that 15 genes (DNAJC19, ETHE1, HTATIP2, HINT1, GLRX2, MTRF1L, MICOS10, MTHFS, MRM3, NUDT9, NDUFB4, RMDN1, SIRT5, and SPATA20, UQCRB) were causally associated with CRC (Figure 3).