TwoSampleMR analysis revealed that 15 genes (DNAJC19, ETHE1, HTATIP2, HINT1, GLRX2, MTRF1L, MICOS10, MTHFS, MRM3, NUDT9, NDUFB4, RMDN1, SIRT5, and SPATA20, UQCRB) were causally associated with CRC (Figure 3). Here, NUDT9 is linked to colorectal carcinoma.