TwoSampleMR analysis revealed that 15 genes (DNAJC19, ETHE1, HTATIP2, HINT1, GLRX2, MTRF1L, MICOS10, MTHFS, MRM3, NUDT9, NDUFB4, RMDN1, SIRT5, and SPATA20, UQCRB) were causally associated with CRC (Figure 3). This evidence concerns the gene GLRX2 and colorectal carcinoma.