In this study, based on 1136 MRGs, by MR and SMR analyses, colocalization analyses, susceptibility validation, PPI networks, integrative genes multi‐omics analysis, and survival analyses, six genes (SCP2, ABCD3, COX10, MICOS10, GCDH, and MTRF1L) were found to be causally associated with CRC, and their high expression levels had a better prognostic significance. This evidence concerns the gene MTRF1L and colorectal carcinoma.