TwoSampleMR analysis revealed that 15 genes (DNAJC19, ETHE1, HTATIP2, HINT1, GLRX2, MTRF1L, MICOS10, MTHFS, MRM3, NUDT9, NDUFB4, RMDN1, SIRT5, and SPATA20, UQCRB) were causally associated with CRC (Figure 3). Here, HTATIP2 is linked to colorectal carcinoma.