TwoSampleMR analysis revealed that 15 genes (DNAJC19, ETHE1, HTATIP2, HINT1, GLRX2, MTRF1L, MICOS10, MTHFS, MRM3, NUDT9, NDUFB4, RMDN1, SIRT5, and SPATA20, UQCRB) were causally associated with CRC (Figure 3). This evidence concerns the gene MRM3 and colorectal carcinoma.