Importantly, the selected neoepitopes include two HLA class I‐restricted peptides from a common AML mutation in NPM1, and an HLA class II‐restricted peptide from a mutation in isocitrate dehydrogenase 2 (IDH2) (R140Q), both of which have been shown to induce memory T cell responses in AML patients [74]. Here, IDH2 is linked to acute myeloid leukemia.