Cytokines are viewed as natural adjuvant candidates for increasing or modulating anti‐tumor effects.[11, 53, 54, 55] However, their systemic administration often leads to uncontrolled distribution and severe inflammatory side effects.[26, 58, 59, 60] To address this, we engineered iPSCs using the RID system to enable red light–inducible expression of IFN‐β. This evidence concerns the gene IFNB1 and neoplasm.