HOXB8 has been described as a target of the microRNA miR-2682-5p in a signaling cascade involving LINC01006-miR-2682-5p-HOXB8 that promotes pancreatic cancer proliferation and metastasis [47], while HOXB6 expression has been reported previously in mouse pancreatic fibroblasts which were not associated with the tumor stroma [23]. Here, HOXB6 is linked to familial pancreatic carcinoma.