Correlation analysis between HOX gene expression and immune cell infiltration in human PDAC and LUAD tissues show that these mechanisms are also present in vivo in at least two different adenocarcinoma types that had relatively high HOXB8 expression and co-culture experiments performed in LUAD and PANC-1 showed that the regulation of immune-cancer cell interaction of HOX genes is conserved. Here, HOXB8 is linked to cancer.