HOXB8 and neoplasm: Medium conditioned by naïve M0 macrophages affected cell viability of siHOXB6 PANC-1 and siHOXB6/8 Calu-3 lung cells and co-culture experiments of siHOXB8 cells with differentiating macrophages showed that reduced HOXB8 expression directed tumor-associated macrophages towards a M1 polarization state.