Interestingly, HOXB6 and HOXB8 bind to and activate expression of one another and other HOX genes expressed in pancreatic cancer cells suggesting that a HOX transcriptional network is active in PDAC (Fig. 5) similarly to what has been described in other solid tumors (reviewed in [48, 49]). The gene discussed is HOXB6; the disease is familial pancreatic carcinoma.