HOXB8 and cancer: Gene expression analysis of HOXB6 and HOXB8 KD cells suggested that HOXB6 and HOXB8 promote PDAC tumorigenesis, but despite of having high molecular similarities the cellular mechanisms involved differ: HOXB6 more strongly promotes expression of genes important for stem cell differentiation whereas HOXB8 and HOXB6 repress expression of genes critical for immune-cancer cell interactions.