WWTR1 and cancer: In contrast, a heterogeneous expression pattern, indicating the coexistence of cells with high YAP/TAZ activity (YAP/TAZhigh)—which demonstrated marked accumulation and nuclear localization of YAP/TAZ—and cells with low YAP/TAZ activity (YAP/TAZlow)—which demonstrated reduced or cytoplasmic localization of YAP/TAZ—were observed in the cancer cells in the tumor tissues of 46 patients (24%) (Fig. 1A).