NFIA and SOX9 have been described as critical transcription factors in the onset of gliogenesis [106, 107] whereas SOX8 has been described as a multiple sclerosis risk gene [108], with a critical role in oligodendrocyte terminal differentiation and myelin maintenance [109], further hinting at epigenetics potentially contributing to impaired oligodendroglial signatures and function, which are especially relevant in FTLD [10, 110, 111]. This evidence concerns the gene SOX8 and multiple sclerosis.