VAMP3 has been implicated in several cellular processes including autophagy, through its role in autophagosome biogenesis [132, 133] and indirectly in neurodegenerative diseases such as AD, due to being regulated by the AD risk factor PICALM (Phosphatidylinositol binding clathrin-assembly protein) [134]. This evidence concerns the gene VAMP3 and neurodegenerative disease.