For example, FSP1 and DHODH neutralize lipid peroxy radicals through CoQ10, Nrf2 suppresses ferroptosis through downstream target genes, and DHCR7 regulates ferroptosis by generating 7-DHC to clear ROS.47,48 However, GPX4, which converts lipid peroxides to lipid alcohols, has been the focus of recent developments in ferroptosis-inducing molecules.2,9,49 GPX4 is also strongly associated with acquired drug resistance and tumor metastasis. The gene discussed is GPX4; the disease is neoplasm.