The synergistic effects of lipid metabolism remain to be resolved: our study focused on the regulatory roles of PCBP1/2 and GPX4, but ACSL4 (acyl coenzyme A synthetase long-chain family member 4) and LOX (lipoxygenase) are highly expressed in colorectal cancer cells, which may synergistically amplify ACE-induced lipid peroxidation by increasing membrane incorporation and oxidation of polyunsaturated fatty acids (PUFAs). This evidence concerns the gene ACSL4 and colorectal cancer.