SYN1 and infection: Upon i.n. VSV instillation, WT and GFAP-Cre± MAVSfl/fl mice survived the infection, while Syn1-Cre± MAVSfl/fl mice showed moderately and CX3CR1-CreER± MAVSfl/fl mice massively enhanced susceptibility to lethal VSV infection when compared with Cre negative littermates (Fig. 2A and Extended Data Fig. 2A).