Another panel that includes CA19-9, apolipoprotein A-IV (APOA4), and TIMP1 demonstrated even greater accuracy in distinguishing early-stage PC from pancreatitis (AUC = 0.934; 86% sensitivity, 90% specificity) [166] Furthermore, a panel consisting of apolipoprotein E (APOE), interalpha-trypsin inhibitor heavy chain H3 (ITIH3), apolipoprotein A-I (APOA1), apolipoprotein L1 (APOL1), and CA19-9 significantly improved the diagnostic sensitivity (95%) and specificity (94.1%) of PC [167]. This evidence concerns the gene APOA4 and pachyonychia congenita.