PIK3CA and pachyonychia congenita: Whole-genome analyses further revealed novel candidate drivers of PC, including KDM6A, PREX2, DNA maintenance genes (BRCA1, BRCA2, and PALB2), and druggable oncogenes (ERBB2, MET, FGFR1, CDK6, PIK3R3, and PIK3CA) [275].