STK11 and skin squamous cell carcinoma: In CSCC, mutations are more often found in genes such as EGFR, SMAD4, ERBB2, ERBB3, ELF3, TGFBR2, CREBBP, MAPK1c, CBFB, ARID1A, NFE2L2, CASP8, STK11, SHKBP1, LKB1, and NOL7. These genes are involved in pathways regulating cell signaling, growth, and differentiation [185, 186].