Through gene ontology analysis, specifically Kyoto Encyclopedia of Genes and Genomes pathways, we found these proteins show enrichment for the pathways EGFR tyrosine kinase inhibitor resistance and PD-L1 expression and PD-1 checkpoint pathway in cancer, among others (Fig. 8, B–D) and contain proteins that are part of EVs and extracellular space (Fig. 8D). This evidence concerns the gene CD274 and cancer.