TLR4 and Stroke: In combination with reperfusion therapies after stroke, many previously developed immune-related drugs, including the toll-like receptor 4 (TLR4) antagonist ApTOLL,11 methylprednisolone,13 edaravone dexborneol,12 fingolimod (FTY-720),14 and bone marrow mononuclear cell transplantation,60 have yielded promising results.