Evidence from APP/PS1, 5xFAD, tau transgenic, and Drosophila models demonstrates that regulators such as methyltransferase-like 3 and fat mass and obesity-associated protein influence Alzheimer's disease progression through neuroinflammation, circular RNAs dysregulation, and autophagy-related mechanisms. The gene discussed is METTL3; the disease is early-onset autosomal dominant Alzheimer disease.