While much TE expression in cancers may reflect nothing more than unwanted transcripts enabled by disturbed epigenetic regulation, the chimeric HERVH-CALB1 transcript detected in cancer [159], has also been observed in human embryonic stem cells and in the epiblast of preimplantation embryos [52, 160], suggesting that it may represent an exaptation event in normal physiology and also functional in cancer-time. Here, CALB1 is linked to cancer.