Integration of differential regulon activity and regulon specificity analyses revealed that certain regulons, including Hivep2, Bcl6, Bcl11a, and Thra, exhibited both decreased activity (Fig. 3e) and increased specificity (Fig. 3g) in vulnerable neurons post-ischemia, suggesting their critical role in neuronal susceptibility to damage. The gene discussed is BCL11A; the disease is ischemia.