These diseases are called tauopathies and include AD as well as several diseases under the FTLD umbrella (FTLD-tau) such as PSP, Pick’s disease, corticobasal degeneration (CBD), argyrophilic grain disease, and frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), most of which are sporadic with the exception of the latter which is caused by mutations in MAPT (such as the MAPT mutation carriers in FTLD2m) [2, 68]. Here, MAPT is linked to Alzheimer disease.